Case Western Reserve University Cystic Fibrosis Mouse Models Core
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The CF mouse shows some level of involvement in nearly every process found in CF patients. Below is a summary of some of the major CF manifestations that are observed in the mouse.

Growth
CF mice are typically between 50-80% of the size of their non-CF littermates (WT). 
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Intestinal obstruction
CF mice display intestinal obstruction at a high rate which decreases survival compared to their non-CF littermates (WT). 
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Lung pathology
While CF mice have a milder lung pathology than CF patients, they do CF mice display intestinal obstruction at a high rate which decreases survival compared to their non-CF littermates (WT). 
​A comprehensive CF mouse model review is below:

Wilke M, Buijs-Offerman RM, Aarbiou J, Colledge WH, Sheppard DN, Touqui L, Bot A, Jorna H, de Jonge HR, Scholte BJ.
J Cyst Fibros. 2011 Jun;10 Suppl 2:S152-71. doi: 10.1016/S1569-1993(11)60020-9.
 
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