The CF mouse shows some level of involvement in nearly every process found in CF patients. Below is a summary of some of the major CF manifestations that are observed in the mouse.
Growth
CF mice are typically between 50-80% of the size of their non-CF littermates (WT).
Growth
CF mice are typically between 50-80% of the size of their non-CF littermates (WT).
Intestinal obstruction
CF mice display intestinal obstruction at a high rate which decreases survival compared to their non-CF littermates (WT).
CF mice display intestinal obstruction at a high rate which decreases survival compared to their non-CF littermates (WT).
Lung pathology
While CF mice have a milder lung pathology than CF patients, they do CF mice display intestinal obstruction at a high rate which decreases survival compared to their non-CF littermates (WT).
While CF mice have a milder lung pathology than CF patients, they do CF mice display intestinal obstruction at a high rate which decreases survival compared to their non-CF littermates (WT).